& BIOMEDICAL ENGINEERING Indian Institute Of Technology Madras

Swathi Sudhakar

Assistant Professor

  1. Cellular nanomechanics
  2. Single-molecule biophysics
  3. Nanoprobes development and Nanotherapeutics
  4. Protein self-assembly and aggregation kinetics
  5. Biomaterials and drug delivery vehicles
  6. Development of Diagnostic devices


 Area of Interest

 I am an Assistant Professor at the Department of Applied Mechanics, Biomedical Engineering at IIT Madras. My research interests are in the field     of biological applications of nanomaterials, drug Delivery, and biophysics. My group is currently working on different streams including         developing nanotherapeutics for Alzheimer’s and Cancer, studying nano mechanics of proteins, and development of biosensors for disease diagnosis

 Office Location

   MSB 221
   Department of Applied Mechanics & Biomedical Engineering (Specializing Fluid and Solid Mechanics)
   Indian Institute of Technology, Madras.
   Chennai, Tamil Nadu- 600036
   Phone :(91)-44- 2257 4087

  • 1. Kavya VB, Thilak Raj, Abirami S, Subastri S, Swathi Sudhakar*, Elucidating shape mediated drug carrier mechanics of hematite nanomaterials on breast cancer therapeutics, RSC Journal of Material Chemistry B, Just accepted Manuscript
  • 2. Sameer S, Kaviya VB, Anisha Kabir, Thilak Raj, and Swathi Sudhakar*. Microgravity as a platform to enhance drug loading in nanomaterials. Journal of drug delivery science and technology (Under Review)
  • 3. Ashuwin Prabhu, Anagha Manohar, Narendran S, Anisha Kabir, and Swathi Sudhakar*. Effect of microgravity on artificial single cell membrane mechanics. Biochemical and Biophysical Research Communication (Under review)
  • 4. Thilak Raj, Srestha Roy, Ashwin Kumar, Basudev Roy, Ethayaraja Mani, Swathi Sudhakar*, Direct measurement of the self-diffusiophoretic force of active colloids using optical tweezers, JCIS (Under Review - 2024)
  • 5. Srisowmeya G, Ethayaraja Mani, Swathi Sudhakar*, Engineering pectin films for packaging, ACS Biomaterials (Under Review - 2024)
  • 6. Selvaraj Vimalraj, Dharunya Govindarajan, Swathi Sudhakar, Renugaa Suresh, Praveenkumar Palanivel, Saravanan Sekaran, Chitosan derived chitooligosaccharides promote osteoblast differentiation and offer anti-osteoporotic potential: Molecular and morphological evidence from a zebrafish model, International Journal of Biological Macromolecules, 2024, Volume 259, Part 2, 129250
  • 7. Kavya VB, Abirami S, Subastri S, Poornima BS, Natasha P, Julia S, Swathi S*, Doxorubicin loaded thermostable nanoarchaeosomes: A next-generation drug carrier for breast cancer therapeutics, Royal Society of Chemistry Nanoscale Advances, 2024, DOI: 10.1039/D3NA00953J.
  • 8. G.Dharunya, S. Sekarana, S.Swathi, Vimalraj. Graphene a multifaceted Carbon-Based Material for Bone Tissue Engineering Applications, ACS Omega, 2023, 9, 1, 67–80.
  • 9. Vimalraj Selvaraj, Swathi Sudhakar, Saravanan Sekaran, Suresh Kumar Rs. Enhancing precision and efficiency: harnessing robotics and artificial intelligence for endoscopic and surgical advancements, International Journal of Surgery, 2023, DOI: 10.1097/JS9.0000000000000936
  • 10. Swathi Sudhakar, Anagha Manohar, Ethayaraja Mani, Liquid Liquid Phase separation of Amyloid beta (1-40) in Alzheimers, ACS Chemical Neuroscience, 2023, 14,19, 3655-3664.
  • 11. Swathi Sudhakar, Pasupathi Rajendran, and Erik Schaeffer, Synthesis of germanium nanospheres as high precision optical tweezers probes, Optical tweezers, springer, 2022.
  • 12. Swathi Sudhakar, Mohammad Kazem Abdosamadi, Tobias Jörg Jachowski, Michael Bugiel, Anita Jannasch & Erik Schäffer*., Germanium nanospheres for ultra resolution picotensiometry of kinesin motors. Science., 2021, 371, eabd9944.
  • 13. Akanksha Dohare*, Swathi Sudhakar*, Björn Brodbeck, Ashutosh Mukherjee, Marc Brecht, Andreas Kandelbauer, Erik Schäffer, Hermann A Mayer. Anisotropic and Amphiphilic Mesoporous Core–core-shell silica Microparticles Provide Chemically Selective Environments for Simultaneous Delivery of Curcumin and Quercetin. Langmuir. 2022.
  • 14. Sriram Krishnamurthy, Swathi Sudhakar, Ethayaraja Mani, Kinetics of aggregation of amyloid β under different shearing conditions: Experimental and modeling analyses, Colloids and Surfaces B: Biointerfaces, 209, Part 1, 2022, 112156, ISSN 0927-7765.
  • 15. Alexandra Ciorîta, Michael Bugiel, Swathi Sudhakar, Erik Schäffer, and Anita Jannasch. Single depolymerizing and transport kinesins stabilize microtubule ends. Cytoskeleton. 2021,78(5)
  • 16. Viktoria Welder, Fäbian struts, Swathi Sudhakar, Gero Lutz Hermsdorf, York Dieter Stierhof, Erik Schäffer., Polycationic gold nanorods as multipurpose in vitro microtubule markers. Nanoscale Adv., 2020, 2, 4003.
  • 17. Swathi Sudhakar, Tobias Jörg Jachowski, Michael Kittelberger, Ammara Maqbool, Gero Lutz Hermsdorf, Mohammad Kazem Abdosamadi, and Erik Schäffer*., Supported Solid Lipid Bilayers as a Platform for Single-Molecule Force Measurements. Nano Lett. 2019, 19, 12, 8877–8886
  • 18. Swathi Sudhakar, Ethayaraja Mani., RapidDissolution of Amyloid β Fibrils by Silver Nanoplates.Langmuir 2019, 35, 21, 6962–6970.
  • 19. Nirmal Kumar Ramesh, Swathi Sudhakar, and Ethayaraja Mani*., Modeling of the Inhibitory Effect of Nanoparticles on Amyloid β Fibrillation. Langmuir 2018, 34, 13, 4004–4012
  • 20. Swathi Sudhakar, Poornima Budime Santhosh, and Ethayaraja Mani. Dual Role of GoldNanorods: Inhibition and Dissolution of Aβ Fibrils Induced by Near IR Laser ACS Chem.Neurosci. 2017, 8, 10, 2325–2334
  • 21. Swathi sudhakar., Kalipillai P., Santhosh P.B., Mani E. Charge on the nanoparticles, not the material composition, affects the inhibition of amyloid beta fibrillation. J. Phys. Chem. C. (2017) 121, 6339– 6348.
  • 22. Santhosh P. B., Thomas N., Sudhakar S., Chadha A., Mani E. Phospholipid stabilized gold nanorods: Towards improved colloidal stability and biocompatibility. Phys. Chem. Chem. Phys. (2017) 19, 18494-1850.
  • 23. S. Sudhakar, P.B. Santhosh. Gold Nanomaterials: Recent Advances in Cancer Theranostics. Advances in Biomembranes and Lipid Self-Assembly, Elsevier, DOI:10.1016/bs. abl.2017. 01. 003. 2017.

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