About Me

Research Interest

  • Applications of optical spectroscopic techniques for in vivo detection of tissue pathologies and physiology
  • Non destructive imaging of tissue using laser speckle techniques
  • Bio-optical signal / image processing
  • Miniaturized optical instrumentation for clinical applications
  • Modeling of light tissue interaction

Office Location

MSB 207C, Biomedical engineering laboratory,
IIT Madras, Chennai - 600036.
Phone: +91 044 2257 4067

Work Experience

  • (August 2018 – present) Professor
    Associate Professor

    Department of Applied Mechanics : Biomedical Engineering Group – Indian Institute of Technology Madras, Chennai, India.

  • (July 2013-2018)Associate Professor
    Associate Professor

    Department of Applied Mechanics : Biomedical Engineering Group – Indian Institute of Technology Madras, Chennai, India.

  • (April 2014-May 2015)Visiting Associate Professor
    Visiting Associate Professor

    School of chemical Biomedical Engineering – NTU, Singapore.

  • (Aug 2006-July 2013)Assistant Professor
    Assistant Professor

    Department of Applied Mechanics : Biomedical Engineering Group – Indian Institute of Technology Madras, Chennai, India.

Academics

  • 2005
    April/May
    Doctor of Philosophy

    Doctor of Philosophy – Nanyang Technological University, Singapore

  • 2000
    April
    Bachelor of Technology

    Calicut University, India

Publications

  • BOOKS

    1. Beam divergence and surface curvature effects in speckle metrology- Recent Developments by Murukeshan VM and N. Sujatha, Chapter 21 (pages: 391-403) in New directions in Holography and Speckle, edited by H. John Caulfield and Chandra S. Vikram, American Scientific Publishers, ISBN: 978-1588831019

    2. Computational signal processing and analysis, Select Proceedings of ICNETS2, Volume I, Nandi, A.K., Sujatha, N., Menaka, R., Alex, J.S.R. (Eds.), Springer, ISBN 978-981-10-8354-9, 2018.

    3. Endoscopic diagnostics in Biomedicine: Instrumentation and Applications, N. Sujatha (in press)


    JOURNALS

    1. Bala Nivetha Kanakaraj, Sujatha Narayanan Unni (2018), “Model-based quantitative optical biopsy in multilayer in-vitro soft tissue models for whole field assessment of nonmelanoma skin cancer,” Journal of Medical Imaging, 5(1), 014506 (2018), doi: 10.1117/1.JMI.5.1.014506.

    2. Adeeba Fathima, Mahima Sharma B.S., Sujatha N.,” Selective sensitivity of Mueller imaging for tissue scattering over absorption changes in cancer mimicking phantoms, Optics and Lasers in Engineering, Volume 102, 2018, Pages 112-118, ISSN 0143-8166, doi: https://doi.org/10.1016/j.optlaseng.2017.10.016

    3. K. Bala Nivetha and Sujatha, N , “Development of thin skin mimicking bilayer solid tissue phantoms for optical spectroscopic studies” (2017), Journal of Biomedical Optics Express, 8 (7), 3198-3212.

    4. Michael Raju and Sujatha Narayanan Unni (2017) Concentration-dependent correlated scattering properties of Intralipid 20% dilutions” (2017) Applied Optics, 56(4):1157-1166.

    5. K. Udayakumar, N. Sujatha and A. R. Ganesan (2017), “Quantitative assessment of soft tissue deformation using digital speckle pattern interferometry: studies on phantom breast models” Journal of Medical Imaging, 4(1), 016001-016009.

    6. N. Sujatha, B. S. Suresh Anand, K. BalaNivetha, V. B. Narayana Murthy, S. Sheshadri and Richa Podda (2015)"Assessment of microcirculatory hemoglobin levels in normal and diabetic subjects using diffuse reflectance spectroscopy: a pilot study" Journal of Applied Spectroscopy, Vol. 82 (3),pp.432-437.

    7. C. Lal and N. Sujatha (2015), Correlation analysis of laser Doppler flowmetry signals- a potential non-invasive tool to assess microcirculatory changes in diabetes mellitus, Journal of Medical and Biological Engineering and Computing, 53, 557-566.

    8. S. Suresh Anand and N. Sujatha (2014), "Diffuse reflectance spectroscopy for monitoring diabetic foot ulcer-A pilot study", Optics and Lasers in Engineering 53, pp. 1-5.

    9. Cerine Lal, A. Banerjee and N. Sujatha (2013), "Role of contrast and fractality of laser speckle image in assessing flow velocity and scatterer concentration in phantom body fluids" Journal of Biomedical Optics ,18 (11), pp. (111419-1)- (111419-7).

    10. S. Suresh Anand and N. Sujatha (2013) "Diffuse reflectance spectroscopy for monitoring diabetic foot ulcer-A pilot study", Optics and Lasers in Engineering (Available online: http://dx.doi.org/10.1016/j.optlaseng.2013.07.020)

    11. B. S. Suresh Anand and N. Sujatha (2012), Fluorescence quenching effects of hemoglobin on simulated tissue phantoms in the UV-Vis range, Measurement Science and Technology, 23,025502-1 - 025502-6.

    12. B. S. Suresh Anand and N. Sujatha (2011), Effects of Intralipid-10% in fluorescence distortion studies on liquid tissue phantoms in UV range", Journal of Biophotonics, 4 (1-2),92-97.

    13. K. Jayanthy, N, Sujatha and M. Ramasubba Reddy (2011) "Laser speckle contrast imaging for analyzing static scatterer concentration in body fluids", Optics and lasers in Engineering. Vol. 49, pp. 553-556.

    14. K. Jayanthy, N, Sujatha and M. Ramasubba Reddy (2011), "Measuring Blood flow: techniques and applications: A review", International journal of research and review in applied sciences, Vol. 6, pp.203-216.

    15. Murukeshan, V. M., Sujatha, N., Ong, L. S., Sing. A. and Seah, L. K. (2007), Effect of image fiber on speckle fringe pattern in image fiber guided DSPI endoscopy. Optics and Laser Technology, 39 (3), pp. 527-531.

    16. Murukeshan, V. M. and Sujatha, N. Unni. (2007) All fiber optic based multi-speckle modality endoscopic system for imaging medical cavities, Review of Scientific Instruments, 78 (5), pp. 053106-1 to 053106-8.

    17. Sujatha, N., Murukeshan, V. M., Rajendran, S., Ong, L. S., and Seah, L. K., (2005) Non-destructive inspection of inner surfaces of technical cavities using digital speckle shearography. Nondestructive Testing and Evaluation, 20 (1), pp. 25-34.

    18. Sujatha, N., Murukeshan V. M and Ganesan A. R., (2005) Effect of illumination beam divergence in DSPI fringe formation. Journal of Holography and Speckle, 2 (1), pp. 20-25.

    19. Murukeshan, V. M., and Sujatha, N., (2005) Integrated simultaneous dual-modality imaging endospeckle fluoroscope system for early colon cancer diagnosis. Optical Engineering Letters, 44(11), pp. 110501.1 - 110501.3

    20. Murukeshan, V. M., and Sujatha, N. (2004). Digital speckle pattern interferometry for deformation analysis of inner surfaces of cylindrical specimens. Applied Optics, 43 (12), pp. 2400-2408.

    21. Murukeshan, V. M., Sujatha, N., and Ganesan, A. R. (2004). Effect of in-plane sensitive component on speckle fringe formation on curved inner surfaces of engineering specimens. Journal of Holography and Speckle, 1 (2), pp. 63-68.

    22. Sujatha, N., and Murukeshan, V. M. (2004). Non-destructive inspection of tissue/tissue like phantom curved surfaces using digital speckle shearography. Optical Engineering, 43(12), pp. 3055-3060.

    23. Sujatha, N., Murukeshan, V. M., Ong, L. S., and Seah, L. K. (2003). An all fiber optic system modeling for the gastrointestinal endoscopy: design concepts and fluorescence analysis. Optics Communications, 219, pp. 71-79.

    CONFERENCES

    1. K. K. Srikarthikeyan, Sujatha Narayanan Unni, Sujatha Narayanan Unni, } "Quantitative single-exposure laser speckle contrast imaging ", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108200Q (23 October 2018); doi: 10.1117/12.2502071; https://doi.org/10.1117/12.2502071

    2. Vivek Sivakumar, Sujatha N., N. J. Vasa, “Low cost laser induced breakdown spectroscopy technique for detection of microorganisms,Proc. SPIE 10753, Ultrafast Nonlinear Imaging and Spectroscopy VI, 1075313 (3 September 2018); doi:10.1117/12.2322980

    3. Sujatha N., Vysakh Vasudevan; Kavyakantha R.S., “Spatially resolved diffuse optical correlation spectroscopy (SR-DOCS) for quantitative assessment of skin tissue perfusion matrix,” Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 1068525 (17 May 2018); doi: 10.1117/12.2307055.

    4. Vysakh V., N. Sujatha (2018), “Light-tissue interaction modelling using COMSOL Multiphysics for multi-layered skin tissues,” COMSOL Conference 2018, Bangalore, India.

    5. B. S. M. Sharma and N. Sujatha, "Assessment of skin fibrosis using Mueller matrix polarimetry," 2018 3rd International Conference on Microwave and Photonics (ICMAP), Dhanbad, 2018, pp. 1-2, doi: 10.1109/ICMAP.2018.8354544

    6. Pauline John, Nilesh Vasa, Sujatha N , and Suresh Rao (2016), "Frequency Domain Optical Coherence Tomography for Measurement of Aqueous Glucose Using Super Continuum Laser Source at Wavelengths 1.6 µm and 2.3 µm," in 13th International Conference on Fiber Optics and Photonics, OSA Technical Digest (online), Th3A.1.

    7. Pauline John, Murali Manoj, N. Sujatha , N. J. Vasa and Suresh R Rao (2015), Aqueous glucose measurement using differential absorption-based frequency domain optical coherence tomography at wavelengths of 1310 nm and 1625 nm, Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371, doi: 10.1117/12.2183830

    8. K. Udayakumar and N. Sujatha (2015), "Estimation of stress relaxation time for normal and abnormal breast phantoms using optical technique", Proceedings of SPIE, Vol. 9302, doi:10.1117/12.2081036.

    9. N. Sujatha and Arnab Banerjee (2015), "An experimental model for minimizing errors in laser speckle contrast imaging for microcirculation analysis", Proceedings of SPIE, Vol. 9302, doi:10.1117/12.2077477.

    10. Michael Raju and N. Sujatha (2015), "Diffuse reflectance based inverse Monte Carlo model for the estimation of the dependent scattering of the Intralipid 20% using a simplified two fiber oblique geometry set up" Proceedings of SPIE, Vol. 9325, doi: 10.1117/12.2079203.

    11. Suresh Anand and N. Sujatha (2015), "Effects of scattering and absorbing medium in the fluorescence conversion efficiency of the physical tissue models", Proceedings of SPIE, Vol. 9325, doi: 10.1117/12.2078870.

    12. K. Udayakumar, N. Sujatha and A. R. Ganesan (2015), "Digital speckle pattern interferometry based anomaly detection in breast mimicking phantoms-a pilot study" Proceedings of SPIE, Vol. 9417, doi: 10.1117/12.2081594.

    13. K. BalaNivetha and N. Sujatha (2015), "Fiber based in vivo imaging of epithelial FAD fluorescence: experiments and simulations" Proceedings of SPIE, Vol. 9417, doi:10.1117/12.208056

    14. K. Jayanthy, N. Sujatha, M. Ramasubba Reddy and V. B. Narayanamoorthy (2014), "Non-invasive blood flow assessment in diabetic foot ulcer using laser speckle contrast imaging technique", Proc. SPIE 8952, Biomedical Applications of Light Scattering VIII, 89521D (March 4, 2014); doi:10.1117/12.2041874.

    15. N. Sujatha, K. BalaNivetha and Akshay Singhal (2014), "Optimal source to detector separation for extracting sub-dermal chromophores in fiber optic diffuse reflectance spectroscopy: a simulation study" Proceedings of SPIE, Vol. 9129, doi:10.1117/12.2048869.

    16. K. BalaNivetha and N. Sujatha (2014) "Understanding the role of hemoglobin in altering multi-layered tissue intrinsic fluorescence in visible region using fiber optics", Proceedings of SPIE, Vol.9098, doi: 10.1117/12.2053634.

    17. R. Sivakumar, N. Sujatha (2014), "Laser based tomographic system for visualization and characterization of tissue optical phantoms, Proceedings of the 2014 International Conference on Communications, Signal Processing and Computers, ISBN: 978-1-61804-215-6.

    18. N. Sujatha and Cerine Lal (2012), Laser based signal and image fractal analysis for assessment of blood flow, Proceedings of SPIE Vol. 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84272M (June 1, 2012); doi:10.1117/12.921743.

    19. Bala Nivetha K, and N. Sujatha (2012), Assessment of surface roughness based on laser Image autocorrelation method, Proceedings of international conference on biomedical signals, systems and imaging, IIT Madras, Nov 28-Dec 1.

    20. Cerine Lal, Arnab Banerjee and N. Sujatha (2012), Fractality Vs Contrast of laser speckle image: A tool for assessing flow velocity and scatterer concentration in phantom body fluids, presented at 1st international meeting on Biophotonics, Tel Aviv, Israel Dec 9-11.

    21. B. S. Suresh Anand, N. Sujatha, V. B. Narayana Murthy, V. Sheshadri and R. Poddar (2011) Clinical applications of diffuse reflectance spectroscopy in normal and prediabetic subjects - A pilot study. IEEE Proceedings on the Defence Science and Research Expo, Singapore, DOI:10.1109/DSR.2011.6026804.

    22. N. Sujatha, A. K. Jayanthy and M. Ramasubba Reddy (2011) Laser speckle contrast imaging for assessing flow velocities and scatterer concentration in capillary phantoms, IEEE Proceedings on Lasers and Electro-Optics Europe conference, Munich, DOI: 10.1109/CLEOE.2011.5943311.

    23. K. Jayanthy, N. Sujatha and M. Ramasubba Reddy (2011) Laser speckle contrast imaging for perfusion monitoring in burn tissue phantoms, International federation of medical and biological engineering (IFMBE) proceedings, 35, pp. 443-446, Springer, ISBN 978-3-642-21729-6.

    24. K. Jayanthy, N. Sujatha and M. Ramasubba Reddy (2011), Non invasive capillary blood flow measurement: Laser speckle and Laser Doppler, Proceedings of International Conference on Bioinformatics, Computational Biology and Biomedical Engineering (ICBCBBE), Paris, pp. 1214-1219.

    25. S. Gayathri and N. Sujatha (2011) Fractal dimension characterization of in vivo laser Doppler flowmetry signals, Physics Proceedia Vol. 19, pp. 49-54.

    26. N. Sujatha, B.S. Suresh Anand, A. K. Jayanthy, V. B. Narayana Murthy, Sheshadri and Richa Poddar (2011), Non invasive assessment of tissue oxygenation and blood flow as a tool for staging diabetes, AIP Conference Proceedings, Vol. 1391 DOI: http://dx.doi.org/10.1063/1.3643662.

    27. K. Jayanthy, N. Sujatha and M. Ramasubba Reddy (2010) "Laser speckle contrast imaging based blood flow analysis in normals and in patients with skin diseases", Proceedings of ICCESS, WASET 69, Singapore.

    28. S. Sajitha and N. Sujatha (2010) "Vocal dose measurements and its potential applications", Proceedings of National Systems Conference, Dec 10-12, NIT Suratkal.

    29. K. Jaynathy, N, Sujatha and M. Ramasubba Reddy (2009) "Laser speckle contrast imaging for analyzing static scatterer concentration in body fluids", Proceedings of International Conference on Optics and Photonics, C1.5.

    30. Sujatha, N., and Murukeshan, V. M. (2004) A dual mode imaging fiberscope system for colon cancer diagnosis,Proceedings of International Conference on Optics and Photonics Cochin, Kerala, pp. 13.

    31. Sujatha, N., Murukeshan, V. M., Ong, L. S., and Seah, L. K. (2004) Application of Digital speckle shearography for NDT of inner curved surfaces of tissue/tissue-like phantoms, presented at International Conference, Optics ad photonics in technology frontier , Tokyo, Japan, 12-15 July.

    32. S. Suresh Anand and N. Sujatha (2010), "Quantification of tissue oxygenation levels using diffuse reflectance spectroscopy", Proceedings of SPIE, Vol. 8173, DOI:10.1117/12.897811.

    33. Murukeshan, V. M., Sujatha, N., Seah, L. K., and Ong, L. S. (2005) An all fiber optic endoscope probe distal end for disease diagnosis in body cavities, Proceedings of SPIE, 5651, pp. 321-331.

    34. Murukeshan, V. M., Sujatha, N., Ong, L. S. and Seah L. K. (2005) A flexible endoscope system for dual mode intracavity investigations, Proceedings of SPIE, Vol. 5686, pp.353-359.

    35. Murukeshan, V. M., Sujatha, N., Ong, L. S., Seah, L. K. (2003). Imaging considerations in fiber optic endoscopy system for the gastrointestinal endoscopy. Proceedings of SPIE, 5143, pp.170-180.

Students

Ph.D

  • A. K. Jayanthy, Assessment of capillary blood flow variations in normal and diseased real / phantom tissues using laser speckle contrast imaging technique (Degree awarded July 2012)
  • B. S. Suresh Anand, Studies on factors affecting quantification of biomarkers of turbid media using optical spectroscopy (Degree awarded July 2013)
  • K. Udayakumar, Early detection of soft tissue anomalies using optical interferometric techniques (Degree awarded July 2018)
  • K. BalaNivetha, Depth resolved tissue fluorescence imaging (Degree awarded July 2018)
  • Pauline John, Optical Coherence Tomography for non invasive glucose detection (co-guidance with Prof. Nilesh Vasa, Engineering Design, Ongoing)
  • Vivek, S, Novel optical probing techniques for disease detection from body fluids and tissues(Ongoing)
  • Mahima Sharma B. S., Novel optical polarimetry based diagnostic systems for biomedical applications (ongoing)
  • Vysakh V., Diffuse optical tomographic systems for tissue structural and functional imaging(ongoing)

M.S

  • Cerine Lal: Fractal based optical image and signal processing for biomedical applications(Completed, July 2014)
  • Michael Raju, Quantification of optical scattering in non-tenuous media (completed, 2016)
  • Adeeba Fathima, Selective optical characterization of biological tissues during malignancy using Mueller polarimetry (completed, 2016)
  • Srikarthikeyan K K,, Laser speckle imaging systems for blood flow imaging with improved sensitivity(ongoing)

M Tech / Dual Degree

  • A. Bama (M Tech): Optimal source design for pulse plethysmography (2008, Completed)
  • B. Rajasekharan (M Tech): Flow cytometry for identification of leukemic cells (2009, Completed)
  • S. Sajitha (M Tech): Speech recognition module for vocally challenged kids (2010, Completed)
  • D. Anudeep (Dual Degree): Non destructive evaluation of human tooth using speckle shearography (2012, Completed)
  • R. Sivakumar (M Tech): Laser transmission tomography system for characterization of optical tissue phantoms (2012, Completed)
  • Pavan Kumar Holla (Dual Degree, co-guidance with Prof. Srinivas Chakravarthy, Dept of Biotechnology): Learning sequences using flip flop neurons (2012, Completed)
  • Akshay Singhal (Dual Degree): Depth sensitivity in diffuse reflectance spectroscopy using fiber optic sensor (2013, Completed)
  • C. Deekshit Kumar (Dual Degree): Simulation analysis of ESPI for microdeformation measurement (2013, Completed)
  • Arnab Banerjee (M Tech): Quantitative laser speckle contrast imaging (2013, Completed)
  • Rahul Jayaprakash (Dual Degree): Quantification of tissue constituents using chemometrics (2013, Completed)
  • M. Sirosh (Dual Degree): Retinal image processing for novel biomedical applications (2014,Completed)
  • Kiran Phillip Issac(M Tech): Fiber optic probe design for morphological analysis of multilayered tissue phantoms for diffuse reflectance spectroscopic studies(2014,Completed)
  • Aditya Bharadwaj(Dual Degree,co-guidance with Prof.Shanthi Bhattacharya,Dept of EEE): Design and construction of a low cost and compact optical coherence tomography system(2015,Completed)
  • Favas, M. P.(Dual degree): Development of an indigenous laser Doppler imaging system (2016, completed)
  • Arun Shaly (Dual Degree): Diffuse correlation spectroscopy for monitoring blood flow (2017, completed)
  • Karthikeya Viswanath (Dual Degree) Design and calibration of a Mueller matrix polarimeter (2017, completed)
  • Kavyakantha R S (Dual Degree, Degree awarded July 2018): Diffuse optics instrumentation for tissue imaging
  • Krishnapriya Venugopal (M Tech, Degree awarded July 2018): Laser speckle image processing for tissue functional imaging

Prospective Students

  • About the lab:

    Biophotonics lab focusses on developing non-invasive tools for disease diagnosis based optical principles. This area is highly application oriented, at the same time deeply involved in the basic sciences. Using physics of light-tissue interaction, we try to extract the chemical composition and architecture of the target tissue to understand the biology of tissue transformation during the progression of diseases. We do simulations for optimal device design, instrumentation and experimentation both at research and clinical application levels. Most projects involve large scale data analysis and interpretation using machine learning techniques. The focus is more on developing clinically viable non-invasive portable units for sensing the physiological conditions in a convenient way. For more details, please visit our website / publications.

  • Desired background:

    Electrical and / or Electronics Engg., Mechanical Engg., Instrumentation Engg., Chemical Engg., Optical engineering, Basic sciences, Biotechnology, Computer Science and Engg with keen interest in device development.

    Research Projects are available in the following areas:

    1. Intracavity perfusion imaging (Instrumentation and Image processing& analysis)

    2. High speed tissue perfusion imaging (Instrumentation and signal processing& analysis)

    3. Light tissue interactions in realistic tissue models for diagnostics and therapeutic applications (Mathematical simulations) and validation using standard optical instruments (data collection and analysis)

    4. Quick tissue analysis for pathology labs (instrumentation and signal analysis)

    5. Development of biochemical sensors using optics (Instrumentation, basic sciences, and data analysis)

    6. Optics in functional imaging: Development of in-vivo devices (Instrumentation, basic sciences and data analysis)

List of Courses Taught



  • AM 5610

    Measurements in mechanics

  • AM 5900

    Instrumentation Laboratory

  • AM 5160

    Biomedical Imaging systems

  • AM 1100

    Engineering Mechanics

  • AM 5140

    Biomedical instrumentation

  • AM 5110

    Biomechanics Laboratory

  • ID 6020

    Research Methodology, Dept Module

  • AM 3020

    Fundamentals of medical instrumentation

  • AM 5100

    Biomedical laser instrumentation

  • BT 1010

    Life Sciences

  • AM 5119

    Physiology for Engineers