Ph.D., Indian Institute of Technology, Bombay, India Thesis: Design and Development of Label-Free Optical Biosensors; Two novel, cost effective and field deployable sensing schemes for detection of bacteria and proteins have been demonstrated (July 2003 - December 2008).
B.E., Andhra University, Visakhapatnam, India (Electronics & Instrumentation) (1998-2002).
| Project Title | Agency | Value (in Lakhs) | Role | Duration |
|---|---|---|---|---|
Multiplexed label-free fiber optic biosensor array for waterborne pathogen detection (Multi-WAP) |
IGSTC, India | 160 | PI with Prof. Subrahmanyam (co-PI) | 2016-19 |
Scanning Kelvin Probe Equipment for Surface and Interface Analyses |
DST, India | 45.52 | Co-PI with Prof. Subrahmanyam (PI) | 2016-18 |
Development Of Microfluidics Based Healthcare Diagnostics |
- | 200 | Co-PI in IITM Team Project | 2015-17 |
Development of SERS based substrates for toxin detection |
DRDE, Gwalior, India | 163.55 | Co-PI with Prof. Subrahmanyam (PI) | 2013-15 |
Plasmonic Biosensors for Clinical Diagnosis |
IIT Madras, India | 15 | PI | 2011-14 |
Biological Applications of Nanotechnology (BANTech) |
University of Idaho, Moscow, USA | - | 2009-10 | |
Functionalized Nanospring-mats for detection of Explosive Materials |
Department of Defense, USA | - | Co-Investigator, | 2009-11 |
Optoelectronic biosensors for waterborne pathogenic bacteria |
Naval Material Research Lab, Ambernath | - | Graduate student | 2004-09 |
Center for excellence in Nanoelectronics |
Ministry of IT & communications, Govt. of India | - | Graduate student | 2006-08 |
Polymeric waveguide based biosensors |
Dept. of Biotechnology, Govt. of India | - | Graduate student | 2006-08 |
Microcantilever based biosensor for cardiac markers (i-sens) |
Dept. of Science & Technology, Govt. of India | - | Graduate student | 2004-05 |
A highly sensitive refractive index sensor and evanescent wave absorbance based sensor is developed by fabricating U-bent optical fiber with very low bend diameters. A simple technique for Plastic optical fiber bending and decladding has been developed. Optimization studies have been carried out theoritically and experimentally and these probes have been utilized for refractive index, force and level sensing applications,...Readmore..
Plasmonic nanomaterials such as gold and silver, with their high extinction coefficient and their sensitivity to the refractive index of the surrounding medium, are useful labels for evanescent wave absorbance based sensors. Preparation, characterization, bio-conjugation and surface immobilization of these nanomaterials onto silica or plastic U-bent optical fiber probe surface is a challenge and several protocols have been utilized successfully by our group,...Readmore...
Detection of biomarkers such as proteins and nucleic acids at very low concentrations is achieved by performing sandwich immunoassays using U-bent optical fiber sensors. Several protocols for efficient analyte detection, reduction of non-specific binding, increased sensitivity using plasmonic bio-conjugates have been developed. There is ongoing research in this field to reach lower limits of detection with better sensitivity and repeatability,...Readmore...
Pathogens absorb light at 280 nm. The U-bent probe, with its increased depth of penetration, can detect the presence of pathogens on the surface, by evanescent wave absorbance measured at 280 nm. Research is being carried out to use suitable bioreceptors and detect target molecules and pathogens present in sample,....Readmore...
Device development towards large scale repeatable fabrication of U-bent fiber optic refractive index sensors; array sensors, distributed sensors, hand-held detectors are ongoing. Research is also carried out towards integration of U-bent optical fiber sensors with microfluidic devices fabricated in-house,...Readmore...
