Protein and DNA detection
Detection of biomarkers such as proteins and nucleic acids at very low concentrations is achieved by performing sandwich immunoassays using U-bent optical fiber sensors. Several protocols for efficient analyte detection, reduction of non-specific binding, increased sensitivity using plasmonic bio-conjugates have been developed. There is ongoing research in this field to reach lower limits of detection with better sensitivity and repeatability.
Schematic of transducer surface functionalization(capture antibody immobilization)
and illustration of sandwich assay with reporter antibody conjugated gold nanoparticle is given below
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