Dr. Arun K. Thittai

Associate Professor

Author image

About Me

Research Interest

  • Biomedical Ultrasound Imaging.
  • Ultrasound Elastography.
  • Image analysis & Processing.
  • Ultrasound Therapeutics .
  • Applications of Acoustic Radiation Force .
  • Pre-clinical US imaging.
  • Multimodal imaging, including Photoacoustics.

Office Location

MSB 232 A, Department of Applied Mechanics,
IIT Madras, Chennai - 600036.
Phone: +91 44 2257 4053
Fax: +91 44 2257 4052

Educational Qualification

  • 2007Ph.D
    Doctor of Philosophy

    Doctor of Philosophy(Electrical Engineering) – University of Houston, TX, USA.

  • 2003
    M.S.
    Master of Science (Research) (Electrical Engineering)

    University of Houston, TX, USA.

  • 2001
    B.E.
    Bachelor of Engineering B.E. Electronics and Communication Engineering

    Shanmuga College of Engineering, Thanjavur, TN,India. (Currently SASTRA Deemed University)

Training

  • Feb 2009-Oct 2009
    Post-doctoral Fellow
    Post-doctoral Fellow

    Department of Radiology, University of Texas Medical school – University of Houston, TX, USA.

  • Oct 2007-Jan 2009
    Post-doctoral Fellow
    Post-doctoral Fellow

    Department of Experimental Diagnostic Imaging, M.D. Anderson Cancer Center, – University of Houston, TX, USA.

Work Experience

  • July 2015- present
    Associate Professor
    Associate Professor

    Department of Applied Mechanics : Biomedical Group – Indian Institute of Technology Madras, Chennai-36

  • March 2014-July 2015
    Assistant Professor
    Assistant Professor

    Department of Applied Mechanics : Biomedical Group – Indian Institute of Technology Madras, Chennai-36

  • Nov 2009-Feb 2014
    Assistant Professor on Tenure Track
    Assistant Professor on Tenure Track

    Department of Radiology – University of Texas Medical school at Houston, Houston, TX, USA

  • 2012-2014
    Adjunct Assistant Professor
    Adjunct Assistant Professor

    Dept. of Electrical and Computer Engineering – University of Houston, TX, USA

Publications

  • Google scholar Link https://scholar.google.co.in/citations?hl=en&user=EScEsvAAAAAJ>
    • Refereed Review Article

      • Ophir, J., Srinivasan, S., Righetti, R., and Thittai, A.K.: Elastography: A decade of progress (2000-2010), Cur. Med. Img. Rev. Special Issue on Elasticity Imaging, 7 (4), 292-312, 2011.
      • Refereed Original Articles in Journals

        • Xia R and Thittai AK.: Method to estimate the deviation from ideal uniaxial compression during freehand elastography, Ultrasonic imaging 37 (1), 70-82, 2015.
        • Thittai, A.K., and Xia, R., An analysis of the segmentation threshold used in axial–shear strain elastography, Ultrasonics 55, 58-64, 2015.
        • Rongmin Xia and Thittai, A.K.: Real-time monitoring of HIFU treatment using axial strain and axial-shear strain elastograms, Ultras. Med. Biol., 40 (3), 485-495, 2014.
        • Rongmin Xia, Guazhi Tao, and Thittai, A.K.: Dynamic Frame-Pairing in Real Time Freehand Elastography, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 61(6), 979-985, 2014.
        • Thittai, A.K., Yamal, J-M, and Ophir, J.: Small breast lesion classification performance using the normalized axial-shear strain area feature. Ultras. Med. Biol., 39 (3), 543-548, 2013.
        • Thittai, A.K., Galaz, B., and Ophir, J.: On the advantages of imaging the axial-shear strain component of the total shear strain in breast tumors. Ultras. Med. Biol., 38(11), 2031–2037, 2012.
        • Thittai, A.K., Yamal, J, Mobbs,L.M., Kraemer-Chant,C.M., Chekuri, S, Garra, B.S., and Ophir, J. Axial-shear strain elastography for breast lesion classification: Initial in vivo results from retrospective data, Ultras. Med. Biol., 37(2), 189–197, 2011.
        • Thittai, A.K., Galaz, B., and Ophir, J.: Visualization of HIFU-induced lesion boundaries by axial-shear strain elastography: A feasibility study, Ultras. Med. Biol., 37(3), 426-433, 2011.
        • Schwartz, D.L., Bankson, J., Bidaut,L., He, Y., Williams,R., Lemos, R., Thittai, A.K., Oh, J., Volgin, A., Soghomonyan, S., Yeh, H., Nishii,R., Mukhopadhay, U., Alauddin,M., Mushkudiani, L., Kuno,N., Krishnan,S., Bornman, W., Lai, S.Y., Powis, G, Hazle,J., and Gelovani, J.: HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance, Mol Cancer Res. 9:259-270, 2011.
        • Thittai, A.K., Galaz, B., and Ophir, J.: Axial-shear strain distributions in an elliptical inclusion model: Experimental validation and in vivo examples with implications to breast tumor classification, Ultras. Med. Biol. 36(5), 1-7, 2010. PMID: 20420971.
        • Thittai, A.K. 1 , Galaz, B., and Ophir, J.: The importance of axial compression verification to the correct interpretation of axial-shear strain elastograms in breast lesions, Ultrasonic Imaging 32, 190-198, 2010.
        • Schwartz,D., Bankson,J., Lemos,R., Thittai,AK., He,Yi., Hostetter,G., Demeure,M., Von Hoff,D., Powis,G.: Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer, Mol. Can. Therap. 9(4),2057-2067,2010.
        • Mitra, J., Glover, J.R., Ktonas, P.Y., ThitaiKumar, A., Mukherjee, A., Karayiannis, N.B., Frost, J.D. Jr, Hrachovy, R.A., Mizrahi, E.M.: A Multi-stage System for the Automated Detection of Epileptic Seizures in Neonatal EEG, Journal of Clinical Neurophysiology 26 (4), 218-226, 2009. PMID: 19602985.
        • Schwartz, D., Powis, G.,Thitai-Kumar, A., He, Y., Bankson, J., Williams, R., Lemos, R., Oh, J., Volgin, A., Soghomonyan, S., Nishii, R., Mukhopadhay, U., Alauddin, M., Peng, Z., Bornman, W., Gelovani, J.: The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects, Mol. Can. Therp. 8(4), 947-958, 2009. PMID: 19372568.
        • Volgin, A., LeRoux, L., Maxwell, D., Schellingerhout, D., Thitai-Kumar, A., He,Y., Gelovani, J., Schwartz, DL. In Vitro 3D Modeling of Host Organ-specific Whole Tumor Responses to Radiation, International Journal of Radiation Oncology* Biology* Physics, 72(1), S682-S683 , 2008.
        • Thitaikumar, A., Ophir, J.: Visualization of Lesion Bonding in Axial-Shear Strain Elastograms of Benign and Malignant Breast Lesions, Cover Image, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 55 (8), 2008.
        • Thitaikumar, A., Mobbs, L.M., Kraemer-Chant, C.M., Garra, B.S and Ophir, J.: Breast Tumor Classification using axial shear strain elastography: a feasibility study. Phys. Med. Biol. 53, 4809-4823, 2008. PMID: 18701768.
        • ThitaiKumar, A., Krouskop, T.A., and Ophir, J.: Visualization of bonding at an inclusion boundary using axial shear strain elastography: A feasibility study, Phys. Med. Biol. 52, 2615-2633, 2007. PMID: 17440256.
        • ThitaiKumar, A., and Ophir, J.: Effect of lesion boundary conditions on axial strain elastograms: A parametric study, Ultras. Med. Biol. 33(9), 1463-1467, 2007. PMID: 17561335.
        • ThitaiKumar, A., Krouskop, T.A., and Ophir, J.: Signal-to- Noise ratio, Contrast-to- Noise ratio, and their trade-offs with resolution in axial-shear elastography, Phys. Med. Biol. 52, 13-28, 2007. PMID: 17183125.
        • Righetti, R., Srinivasan, S., Kumar, A.T., Krouskop, T.A., and Ophir, J.: Assessing image quality in effective poisson's ratio elastography and poroelastography - part I, Phys. Med. Biol. 52, 1303-1320, 2007. PMID: 17301456.
        • Righetti, R., Srinivasan, S., Kumar, A.T., Krouskop, T.A., and Ophir, J.: Assessing image quality in effective poisson's ratio elastography and poroelastography - part II, Phys. Med. Biol. 52, 1321-1333,2007. PMID: 17301457.
        • ThitaiKumar, A., Righetti, R., Krouskop, T.A., and Ophir, J.: Resolution of axial-shear strain elastography, Phys. Med. Biol. 51, 5245-5257, 2006. PMID: 17019036.
        • Kumar, A.T., Ophir, J., and Krouskop, T.A.: Noise performance and signal-to- noise ratio of shear strain elastograms, Ultrasonic imaging 27, 145-165, 2005. PMID: 16550705.
        • Conference Publications (Peer-reviewed)

          • Sowmiya C, Ali Arshad K, and Arun K. Thittai " Rotation elastogram: a novel method to visualize local rigid body rotation under quasi-static compression ", Proc. SPIE 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography, pages 97901E1-E8 (April 1, 2016); doi:10.1117/12.2216828;
          • Bhaskara Rao C, Sumramani Vikram , and Thittai AK.: Automatic selection of representative frames from axial-shear strain elastogram (ASSE) cine-loop. Proceedings of the 14th International Tissue Elasticity Conference, Bardolina, Verona, Italy, P41, 2015
          • Lokesh B, Bhaskara Rao C, and Thittai AK.: Improving rotation elastogram quality using synthetic aperture technique. Proceedings of the 14th International Tissue Elasticity Conference, Bardolina, Verona, Italy, P79, 2015
          • Rongmin Xia and Thittai, A.K.: Real-time monitoring of HIFU ablation using axial strain and axial-shear strain elastograms. Proceedings of the Twelfth International Conference on Ultrasonic Measurement and Imaging of Tissue Elasticity, Lingfield, Surrey, UK, p 84, 2013.
          • Rongmin Xia and Thittai, A.K.: Dynamic Frame-Pairing in Real Time Freehand Elastography. Proceedings of the Twelfth International Conference on Ultrasonic Measurement and Imaging of Tissue Elasticity, Lingfield, Surrey, UK, p 41, 2013.
          • Khalil, E.G., Thittai, A.K., Garra, B, and Ophir, J.: Axial Shear Strain Elastography in Benign and Malignant Breast Disease: Preliminary Prospective freehand in vivo data. Proceedings of the Twelfth International Conference on Ultrasonic Measurement and Imaging of Tissue Elasticity, Lingfield, Surrey, UK, p 65, 2013.
          • Thittai, A.K., Galaz, B., and Ophir, J.: On the advantages of imaging the axial-shear strain component of the total shear strain in breast tumors. Proceedings of the Eleventh International Conference on Ultrasonic Measurement and Imaging of Tissue Elasticity, Deauville, France, p 50, 2012.
          • Thittai, A.K., Yamal, J-M., and Ophir, J.: Small breast lesion classification performance using the normalized axial-shear strain area feature. Proceedings of the Tenth International Conference on Ultrasonic Measurement and Imaging of Tissue Elasticity, Arlington, Texas, USA, p 43, 2011.
          • Thittai, A.K., Yamal, J.M., Mobbs, L.M., Kraemer–Chant, C.M., Chekuri, S., Garra, B.S., Ophir, J.: Axial-shear strain elastography for breast lesion classification: initial in vivo results from retrospective data. Proc. of the 9 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, Snowbird, Utah, USA, p102, 2010.
          • Thitai Kumar, A., Galaz, B., Miller, R., and Ophir, J.: Axial-shear strain distributions in beef muscle samples under load: an in vitro study. Proc. of the 8 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, Vlissingen, Zeeland, Netherlands, p50, 2009.
          • Thitai Kumar, A., Galaz, B., and Ophir, J.: Axial-shear strain distributions in an elliptical inclusion model (part II): Experimental validation and in vivo examples with implications to breast tumor classification. Proc. of the 8 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, Vlissingen, Zeeland, Netherlands, p100, 2009.
          • Galaz,B., Thitai Kumar, A., and Ophir, J.: Axial-shear strain distributions in an elliptical inclusion model (part I): A simulation study. Proc. of the 8 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, Vlissingen, Zeeland, Netherlands, p99, 2009.
          • Thitai-Kumar, A., Hazel, J., Gelovani, J., Bankson, J., and Schwartz, D.: Registered MRI-US Imaging Platform for Preclinical Imaging - A Feasibility Study. World Molecular Imaging Congress, Nice, France, 2008.
          • Volgin, A., LeRoux, L., Maxwell, D., Schellingerhout, D., Thitai-Kumar, A., He, Y., Gelovani, J., and Schwartz, D.: 3D Modeling of Host Organ-Specific Whole Tumor Responses to Radiation. World Molecular Imaging Congress, Nice, France, 2008.
          • Volgin, A., LeRoux, L., Maxwell, D., Schellingerhout, D., Thitai-Kumar, A., He, Y., Gelovani, J., and Schwartz, D.: In Vitro 3D Modeling of Host Organ-Specific Whole Tumor Responses to Radiation. Annual meeting of the American Society of Therapeutic Radiology and Oncology, Boston, MA, 2008.
          • Khaled, W., Chekuri, S., Thitai Kumar, A., Ophir, J., Mobbs, L.M., Garra, B.S.: Real-Time imaging of breast tumors invivo using axial and axial-shear strain elastograms: a preliminary study. Proc. of the 7 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 72, 2008.
          • Zahiri–Azar,R., Thitai Kumar, A., Ophir, J., and Salcudean, S.E.: Real–time axial shear strain elastography. Proc. of the 6 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 36, 2007.
          • Thitai Kumar, A, Ophir, J, Chant, C.M, Mobbs, L.M,Garra, B.S.: Visualization of inclusion- background bonding using axial-shear strain elastography: preliminary in vivo images. Proc. of the 6 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 125, 2007.
          • Righetti, R., Srinivasan, S., Thitai Kumar,A., Ophir,J., and Krouskop, T.A.: Image quality issues in poroelastography. Proc. of the 5 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 46, 2006.
          • ThitaiKumar, A., Ophir, J., and Krouskop, T.A.: Interface bonding strength in axial-shear strain elastography. Proc. of the 5 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 54, 2006.
          • Thitai Kumar, A., Righetti, R., Ophir, J and Krouskop, T.A.: Resolution of axial-shear strain elastography. Proc. of the 5 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 69, 2006.
          • ThitaiKumar, A., Ophir, J and Krouskop, T.A.: SNR, CNR and their trade-offs with resolution in axial-shear strain elastography. Proc. of the 5 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 108, 2006.
          • ThitaiKumar, A., Ophir J, and Krouskop T.A.: Comparison between axial elastograms of a connected and disconnected inclusion in homogeneous background: A simulation study. Proc. Of the 4 th International Conference on Ultrasonic Measurement of Imaging of Tissue Elasticity, pp 49 2005.
          • ThitaiKumar, A., Muktevi, V.M., Glover, J.R., Ktonas, P.Y., Frost, J.D., Hrachovy, R.A., Mizrahi, E.M.: Automated Detection of Epileptic Seizure Segments in the Neonatal EEG. Proc. of the HSEMB conference 2003.
          • Glover, J.R., Ktonas,P.Y., Shastry,M., ThitaiKumar, A., Muktevi,V., Frost,J.D., Hrachovy,R.A., Mizrahi,E.M.: Methodology and System Architecture for Automated Detection Of Epileptic Seizures. Proc. of the IEEE-EMBS conference, PP 70-72 2002.

    Students

    Current Ph.D

    • Lokesh B, Topic: Synthetic Aperture Beamforming Technique in Ultrasound Elastography
    • Aliarshad K Topic: Spatial compounding approaches to improve lateral motion tracking in Ultrasound Elastography
    • Sathiyamoorthy S , Topic: Novel and Affordable Ultrasound elastography system for Liver disease assessment
    • Sowmiya C, Topic: Development of Affordable Photoacoustic -B-mode-Elastography imaging system for use in breast imaging applications
    • SenthilKumar P, Topic: Non-invasive Assessment of Portal Pressure using Mechanical modeling and measurements from US elastography,
      (Co-guidance: Dr. Krishnakumar R,ED)
    • Anila Sathish, Topic: Ultrasound Beamforming using Sparse Array/ compressed sensing approaches
    • Anand R, Topic: TBD

    Current M Tech / Dual Degree

    • Dvijendra kumar Patel (MTech BioMed)
    • Prince Chaturvedi (MTech BioMed)
    • Ankit Raj ( AE-BM)
    • Aparna Mohan ( EE-EE)
    • Dhruv Prakash (EE-BM)

    Alumni

    • Chintada Bhaskara Rao (M.S.), Topic: A Novel Elastographic Frame Quality Indicator and Its Use in Automatic Representative Frames Selection from a Cine-loop
    • Vikram A (AE-AM) (Dual degree), Topic: Automatic frame selection from elastographic cine-loop for radiologist evaluation
    • Prakhar Lad (Biomed) (M.tech), Topic: Beam forming implementation in GPU
    • Dhaval M (Biomed) (M.tech), Topic: Software Implementation of robust real-time Displacement Tracking algorithm for US elastography
    • Prakriti (EE-AM) (Dual degree), Topic: Software Implementation of CT reconstruction in GPU
    • Ravi Kiran (EE-AM) (Dual degree), Topic: US Data acquisition system development
    • Sivaramakrishna (B.tech), Topic: 1D motion tracking using sequential ultrasound frames

    List of Courses Taught



    • AM 1100

      Engineering Mechanics

    • AM 5160

      Biomedical Imaging Systems

    • AM 5020

      Biomedical Ultrasonics

    • AM 5110

      Biomechanics Lab

    • ID 6021

      Introduction to Research

    • AM 5130

      Biomedical Signal and Systems